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Genome-wide profiling of gene expression of normal and Tbx20 knockout adult mouse whole heart

ABSTRACT: Tbx20 is a transcription factor important for heart development. To assess the role of Tbx20 in the adult heart, we generated a conditional knockout for this gene, specifically in cardiomyocytes. We profiled gene expression levels using RNA-seq in both normal and knockout adult mouse hearts to identify genes and pathways regulated by Tbx20. The article describing the Tbx20 knockout mouse is under review, a reference will be added when published.

ORGANISM(S): Mus musculus

PROVIDER: GSE30943 | GEO | 2012/02/10

SECONDARY ACCESSION(S): PRJNA146301

REPOSITORIES: GEO

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Genome-wide profiling of gene expression of normal and Tbx20 knockout adult mouse whole heart

Project description:Tbx20 is a transcription factor important for heart development. To assess the role of Tbx20 in the adult heart, we generated a conditional knockout for this gene, specifically in cardiomyocytes. We profiled gene expression levels using RNA-seq in both normal and knockout adult mouse hearts to identify genes and pathways regulated by Tbx20. The article describing the Tbx20 knockout mouse is under review, a reference will be added when published. Analysis of triplicate mRNA samples of adult mouse, comparing normal and knockout

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