Unknown,Transcriptomics,Genomics,Proteomics

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Dynamic Transformations of Genome-wide Epigenetic Marking and Transcriptional Control Establish T Cell Identity


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE31233: Dynamic transformations of epigenetic marking and genome-wide transcriptional regulation that establish T cell identity [ChIP-Seq] GSE31234: Dynamic transformations of epigenetic marking and genome-wide transcriptional regulation that establish T cell identity [RNA-Seq] Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Jingli Zhang 

PROVIDER: E-GEOD-31235 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Dynamic transformations of genome-wide epigenetic marking and transcriptional control establish T cell identity.

Zhang Jingli A JA   Mortazavi Ali A   Williams Brian A BA   Wold Barbara J BJ   Rothenberg Ellen V EV  

Cell 20120401 2


T cell development comprises a stepwise process of commitment from a multipotent precursor. To define molecular mechanisms controlling this progression, we probed five stages spanning the commitment process using RNA-seq and ChIP-seq to track genome-wide shifts in transcription, cohorts of active transcription factor genes, histone modifications at diverse classes of cis-regulatory elements, and binding repertoire of GATA-3 and PU.1, transcription factors with complementary roles in T cell devel  ...[more]

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