Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Jingli Zhang
PROVIDER: E-GEOD-31235 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Zhang Jingli A JA Mortazavi Ali A Williams Brian A BA Wold Barbara J BJ Rothenberg Ellen V EV
Cell 20120401 2
T cell development comprises a stepwise process of commitment from a multipotent precursor. To define molecular mechanisms controlling this progression, we probed five stages spanning the commitment process using RNA-seq and ChIP-seq to track genome-wide shifts in transcription, cohorts of active transcription factor genes, histone modifications at diverse classes of cis-regulatory elements, and binding repertoire of GATA-3 and PU.1, transcription factors with complementary roles in T cell devel ...[more]