Unknown,Transcriptomics,Genomics,Proteomics

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Expression data from mouse heart deficient of HDAC3

ABSTRACT: Gene expression changes in the heart of MCH3-KO mouse (HDAC3 f/f, Muscle Creatine Kinase-Cre) versus control WT mouse (HDAC3 f/f). Histone deacetylases (HDACs) play important roles in cardiac development and function. We show here that mice deficient of HDAC3 in heart and skeletabl muscle are relatively normal on normal chow, but develop hypertrophic cardiomyopathy and heart failure that leads to death on high-fat diet. This microarray experiment is to explore the underlying molecular mechanism. Hearts from 6-weeks old WT and MCH3-KO C57BL/6 mice (n=4 in each group, male) on normal chow were subjected to RNA extraction and Affymetrix Mouse Gene 1.0ST analysis.

ORGANISM(S): Mus musculus

SUBMITTER: Zheng Sun 

PROVIDER: E-GEOD-31251 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Diet-induced lethality due to deletion of the Hdac3 gene in heart and skeletal muscle.

Sun Zheng Z   Singh Nikhil N   Mullican Shannon E SE   Everett Logan J LJ   Li Li L   Yuan Lijun L   Liu Xi X   Epstein Jonathan A JA   Lazar Mitchell A MA  

The Journal of biological chemistry 20110801 38

Many human diseases result from the influence of the nutritional environment on gene expression. The environment interacts with the genome by altering the epigenome, including covalent modification of nucleosomal histones. Here, we report a novel and dramatic influence of diet on the phenotype and survival of mice in which histone deacetylase 3 (Hdac3) is deleted postnatally in heart and skeletal muscle. Although embryonic deletion of myocardial Hdac3 causes major cardiomyopathy that reduces sur  ...[more]

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