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Gene expression in the adrenal glands of two spontaneously hypertensive rat strains at 3 and 6 weeks of age

ABSTRACT: We examined gene expression profiles in the rat adrenal glands using genome-wide microarray technology, and determined gene expression profiles in 3 rat strains: normotensive WKY, spontaneously hypertensive rats (SHR), and stroke-prone SHR (SHRSP). To identify candidate genes involved in the genesis of hypertension in the SHR strains, we compared the gene expression levels at 3 and 6 weeks of age, isolated 407 genes showing a more than 4-fold increase or a less than 1/4-fold decrease. The rat adrenal glands derived from normotensive WKY, spontaneously hypertensive rats (SHR), and stroke-prone SHR (SHRSP) wereM-cM-^@M-^@examined. Each strain was run in triplicate.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Daisuke Okuzaki

PROVIDER: E-GEOD-31457 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genetic analysis of genes causing hypertension and stroke in spontaneously hypertensive rats.

Yamamoto Hideyuki H Okuzaki Daisuke D Yamanishi Kyosuke K Xu Yunfeng Y Watanabe Yuko Y Yoshida Momoko M Yamashita Akifumi A Goto Naohisa N Nishiguchi Seiji S Shimada Kazunori K Nojima Hiroshi H Yasunaga Teruo T Okamura Haruki H Matsunaga Hisato H Yamanishi Hiromichi H

International journal of molecular medicine 20130315 5

Spontaneously hypertensive rats (SHR) and stroke-prone SHR (SHRSP) are frequently used as model rats not only in studies of essential hypertension and stroke, but also in studies of attention deficit hyperactivity disorder (ADHD). Normotensive Wistar-Kyoto rats (WKY) are normally used as controls in these studies. In this study, using these rats, we aimed to identify the genes causing hypertension and stroke, as well as the genes involved in ADHD. Since adrenal gland products can directly influe ...[more]

PMID: 23525202

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