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Gene expression in the whole brains of two spontaneously hypertensive rat strains at 3 and 6 weeks of age

ABSTRACT: We examined gene expression profiles in the rat whole brains using genome-wide microarray technology, and determined gene expression profiles in 3 rat strains: normotensive WKY, spontaneously hypertensive rats (SHR), and stroke-prone SHR (SHRSP). To identify candidate genes involved in the genesis of hypertension in the SHR strains, we compared the gene expression levels at 3 and 6 weeks of age, isolated 407 genes showing a more than 4-fold increase or a less than 1/4-fold decrease. The rat whole brains derived from normotensive WKY, spontaneously hypertensive rats (SHR), and stroke-prone SHR (SHRSP) wereã??examined. Each strain was run in triplicate.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Daisuke Okuzaki

PROVIDER: E-GEOD-41452 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Analysis of genes causing hypertension and stroke in spontaneously hypertensive rats: gene expression profiles in the brain.

Yoshida Momoko M Watanabe Yuko Y Yamanishi Kyosuke K Yamashita Akifumi A Yamamoto Hideyuki H Okuzaki Daisuke D Shimada Kazunori K Nojima Hiroshi H Yasunaga Teruo T Okamura Haruki H Matsunaga Hisato H Yamanishi Hiromichi H

International journal of molecular medicine 20140122 4

Spontaneously hypertensive rats (SHR) and stroke-prone SHR (SHRSP) are frequently used as rat models not only of essential hypertension and stroke, but also of attention-deficit hyperactivity disorder (ADHD). Normotensive Wistar-Kyoto rats (WKY) are used as the control rats in these cases. An increasing number of studies has demonstrated the critical role of the central nervous system in the development and maintenance of hypertension. In a previous study, we analyzed the gene expression profile ...[more]

PMID: 24452243

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