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DNA-Seq of DrosDel deficiency lines and w1118 lines

ABSTRACT: DNASeq reads from pools of female or male DrosDel and w1118 (parental strain for the Df/+ flies). Samples are named in this dataset according to the following sample naming scheme: tissue_genotype shorthand_sex_DNASeq_biological replicate #. We sequenced DNA from pools of female or male DrosDel and w1118 (parental strain for the Df/+ flies).

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Brian Oliver

PROVIDER: E-GEOD-31550 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Mediation of Drosophila autosomal dosage effects and compensation by network interactions.

Malone John H JH Cho Dong-Yeon DY Mattiuzzo Nicolas R NR Artieri Carlo G CG Jiang Lichun L Dale Ryan K RK Smith Harold E HE McDaniel Jennifer J Munro Sarah S Salit Marc M Andrews Justen J Przytycka Teresa M TM Oliver Brian B

Genome biology 20120424 4

<h4>Background</h4>Gene dosage change is a mild perturbation that is a valuable tool for pathway reconstruction in Drosophila. While it is often assumed that reducing gene dose by half leads to two-fold less expression, there is partial autosomal dosage compensation in Drosophila, which may be mediated by feedback or buffering in expression networks.<h4>Results</h4>We profiled expression in engineered flies where gene dose was reduced from two to one. While expression of most one-dose genes was ...[more]

PMID: 22531030

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2012-04-02 | E-GEOD-31407 | biostudies-arrayexpress

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2012-04-03 | E-GEOD-31549 | biostudies-arrayexpress

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