Unknown,Transcriptomics,Genomics,Proteomics

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Expression changes in Yy1 knock down mouse embryonic stem cells


ABSTRACT: We have determined the global gene expression upon loss of function of the Yy1 transcription factor in mouse embryonic stem cells Total RNA was extracted from ES cells transiently transfected with yy1-specific or scrampled-control siRNA oligos 48 hr post-transfection.

ORGANISM(S): Mus musculus

SUBMITTER: Diego Pasini 

PROVIDER: E-GEOD-31784 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Yin Yang 1 extends the Myc-related transcription factors network in embryonic stem cells.

Vella Pietro P   Barozzi Iros I   Cuomo Alessandro A   Bonaldi Tiziana T   Pasini Diego D  

Nucleic acids research 20111230 8


The Yin Yang 1 (YY1) transcription factor is a master regulator of development, essential for early embryogenesis and adult tissues formation. YY1 is the mammalian orthologue of Pleiohomeotic, one of the transcription factors that binds Polycomb DNA response elements in Drosophila melanogaster and mediates Polycomb group proteins (PcG) recruitment to DNA. Despite several publications pointing at YY1 having a similar role in mammalians, others showed features of YY1 that are not compatible with P  ...[more]

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