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Epigenome profiling of repressive histone modifications, DNA methylation and gene expression in normal and malignant urothelial cells

ABSTRACT: To gain a more depth knowledge of repressive epigenetic gene regulation in UCC, we have profiled H3K9m3 and H3K27m3 in normal and malignant urothelial cells. We matched these profiles to those 5-methylcytosine and gene expression. We hypothesized that differences represent pro-carcinogenic events within the urothelium. We identified a panel of genes with cancer specific epigenetic mediated aberrant expression. Two repressive histone modifications (H3K9m3 and H3K27m3) , cytosine methylation and gene expression were compared between normal human urothelial cell line (NHU) and malignant urothelial cells (EJ and RT112).

ORGANISM(S): Homo sapiens

SUBMITTER: Ewa Dudziec

PROVIDER: E-GEOD-31864 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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