Epigenome profiling of repressive histone modifications, DNA methylation and gene expression in normal and malignant urothelial cells
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ABSTRACT: To gain a more depth knowledge of repressive epigenetic gene regulation in UCC, we have profiled H3K9m3 and H3K27m3 in normal and malignant urothelial cells. We matched these profiles to those 5-methylcytosine and gene expression. We hypothesized that differences represent pro-carcinogenic events within the urothelium. We identified a panel of genes with cancer specific epigenetic mediated aberrant expression.
ORGANISM(S): Homo sapiens
PROVIDER: GSE31864 | GEO | 2011/09/20
SECONDARY ACCESSION(S): PRJNA155251
REPOSITORIES: GEO
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