Dataset Information
Viral small RNAs from Drosophila melanogaster flies infected with FHVdeltaB2 or FHV.
Ontology highlight
ABSTRACT:
ORGANISM(S): Drosophila melanogaster
SUBMITTER: JUAN JOVEL
PROVIDER: E-GEOD-32011 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
RNA-based immunity terminates viral infection in adult Drosophila in the absence of viral suppression of RNA interference: characterization of viral small interfering RNA populations in wild-type and mutant flies.
Journal of virology 20110928 24
Replication of viral RNA genomes in fruit flies and mosquitoes induces the production of virus-derived small interfering RNAs (siRNAs) to specifically reduce virus accumulation by RNA interference (RNAi). However, it is unknown whether the RNA-based antiviral immunity (RVI) is sufficiently potent to terminate infection in adult insects as occurs in cell culture. We show here that, in contrast to robust infection by Flock house virus (FHV), infection with an FHV mutant (FHVΔB2) unable to express ...[more]
