Glioma cells oxygen response
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: didier wion
PROVIDER: E-GEOD-32100 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Hypoxia-induced expression of VE-cadherin and filamin B in glioma cell cultures and pseudopalisade structures.
Nissou Marie-France MF El Atifi Michèle M Guttin Audrey A Godfraind Catherine C Salon Caroline C Garcion Emmanuel E van der Sanden Boudewijn B Issartel Jean-Paul JP Berger François F Wion Didier D
Journal of neuro-oncology 20130331 2
Most of our knowledge regarding glioma cell biology comes from cell culture experiments. For many years the standards for glioma cell culture were the use of cell lines cultured in the presence of serum and 20 % O2. However, in vivo, normoxia in many brain areas is in close to 3 % O2. Hence, in cell culture, the experimental value referred as the norm is hyperoxic compared to any brain physiological value. Likewise, cells in vivo are not usually exposed to serum, and low-passaged glioma neurosph ...[more]
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