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Gene induction and repression during terminal erythropoiesis are mediated by distinct epigenetic changes.

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE27893: Genome-wide maps of chromatin state in early erythroid precursors versus later, more differentiated erythroblasts. GSE32110: RNA-seq expression profiles during terminal erythropoiesis Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Bill Wong

PROVIDER: E-GEOD-32111 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene induction and repression during terminal erythropoiesis are mediated by distinct epigenetic changes.

Wong Piu P Hattangadi Shilpa M SM Cheng Albert W AW Frampton Garrett M GM Young Richard A RA Lodish Harvey F HF

Blood 20110822 16

It is unclear how epigenetic changes regulate the induction of erythroid-specific genes during terminal erythropoiesis. Here we use global mRNA sequencing (mRNA-seq) and chromatin immunoprecipitation coupled to high-throughput sequencing (CHIP-seq) to investigate the changes that occur in mRNA levels, RNA polymerase II (Pol II) occupancy, and multiple posttranslational histone modifications when erythroid progenitors differentiate into late erythroblasts. Among genes induced during this developm ...[more]

PMID: 21860024

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