Unknown,Transcriptomics,Genomics,Proteomics

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Development of Transcriptomic Biomarker Signature in Human Saliva to Detect Lung Cancer


ABSTRACT: Affymetrix HG U133 Plus 2.0 Array (Affymetrix, Santa Clara, CA) was used to profile transcriptomes and discover altered gene expression in saliva supernatant. Salivary transcriptomic biomarker discovery was performed on 10 lung cancer patients and 10 matched controls. Seven messenger RNA biomarkers were discovered and pre-validated This study consisted of two phases, including a discovery phase, followed by a pre-validation phase. 10 lung cancer samples and 10 matched control samples were chosen for the biomarker discovery phase. The transscriptomic approach profiled the saliva supernatant samples from 10 lung cancer patients and 10 healthy control subjects using the Affymetrix HG U133 Plus 2.0 Array (Affymetrix, Santa Clara, CA). Biomarkers identified from the microarray study were first verified using the discovery sample set (10 lung cancer and 10 healthy control).

ORGANISM(S): Homo sapiens

SUBMITTER: Hua Xiao 

PROVIDER: E-GEOD-32175 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Development of transcriptomic biomarker signature in human saliva to detect lung cancer.

Zhang Lei L   Xiao Hua H   Zhou Hui H   Santiago Silverio S   Lee Jay M JM   Garon Edward B EB   Yang Jieping J   Brinkmann Ole O   Yan Xinmin X   Akin David D   Chia David D   Elashoff David D   Park No-Hee NH   Wong David T W DTW  

Cellular and molecular life sciences : CMLS 20120612 19


Lung cancer is the leading cause of cancer death for both men and women worldwide. Since most of the symptoms found for lung cancer are nonspecific, diagnosis is mostly done at late and progressed stage with the consecutive poor therapy outcome. Effective early detection techniques are sorely needed. The emerging field of salivary diagnostics could provide scientifically credible, easy-to-use, non-invasive and cost-effective detection methods. Recent advances have allowed us to develop discrimin  ...[more]

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