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Apoptosis pathway analysis of genes from macropahges infected with Histoplasma capsulatum

ABSTRACT: Analyzed 84 genes from macrophages infected with Histoplasma capsulatum for changes in expression over 24 hours Macrophages infected with Histoplasma capsulatum were analyzed for alterations in apoptosis genes, 5 biological replicate (rep1-5)

ORGANISM(S): Mus musculus

SUBMITTER: George Deepe

PROVIDER: E-GEOD-32965 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Deciphering the pathways of death of Histoplasma capsulatum-infected macrophages: implications for the immunopathogenesis of early infection.

Deepe George S GS Buesing William R WR

Journal of immunology (Baltimore, Md. : 1950) 20111118 1

Apoptosis of leukocytes is known to strongly influence the immunopathogenesis of infection. In this study, we dissected the death pathways of murine macrophages (MΦs) infected with the intracellular pathogen Histoplasma capsulatum. Yeast cells caused apoptosis of MΦs at a wide range of multiplicity of infection, but smaller inocula resulted in delayed detection of apoptosis. Upon infection, caspases 3 and 1 were activated, and both contributed to cell death; however, only the former was involved ...[more]

PMID: 22102723

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