Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: John Newman
PROVIDER: E-GEOD-3407 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Newman John C JC Bailey Arnold D AD Weiner Alan M AM
Proceedings of the National Academy of Sciences of the United States of America 20060613 25
Cockayne syndrome (CS) is an inherited neurodevelopmental disorder with progeroid features. Although the genes responsible for CS have been implicated in a variety of DNA repair- and transcription-related pathways, the nature of the molecular defect in CS remains mysterious. Using expression microarrays and a unique method for comparative expression analysis called L2L, we sought to define this defect in cells lacking a functional CS group B (CSB) protein, the SWI/SNF-like ATPase responsible for ...[more]