Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Mitch Kronenberg
PROVIDER: E-GEOD-34179 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Engel Isaac I Zhao Meng M Kappes Dietmar D Taniuchi Ichiro I Kronenberg Mitchell M
Blood 20121003 23
The majority of mouse Vα14 invariant natural killer T (Vα14i NKT) cells produce several cytokines, including IFNγ and IL-4, very rapidly after activation. A subset of these cells, known as NKT17 cells, however, differentiates in the thymus to preferentially produce IL-17. Here, we show that the transcription factor-known as T helper, Poxviruses, and Zinc-finger and Krüppel family, (Th-POK)-represses the formation of NKT17 cells. Vα14i NKT cells from Th-POK-mutant helper deficient (hd/hd) mice ha ...[more]