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Temporal expression of miR-17-92a regulates effector and memory CD8+ T cell differentiation

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE34216: miRNA signatures of antigen specific CD8+ T cells at different stages of immune response to LCMV infection GSE34217: Expression profile of miR-17-92a-MSCV-IRES-Thy1.1 transduced P14 CD8+ T cells Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Tuoqi Wu

PROVIDER: E-GEOD-34218 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Temporal expression of microRNA cluster miR-17-92 regulates effector and memory CD8+ T-cell differentiation.

Wu Tuoqi T Wieland Andreas A Araki Koichi K Davis Carl W CW Ye Lilin L Hale J Scott JS Ahmed Rafi R

Proceedings of the National Academy of Sciences of the United States of America 20120604 25

MicroRNAs are important regulators of various developmental and physiological processes. However, their roles in the CD8(+) T-cell response are not well understood. Using an acute viral infection model, we show that microRNAs of the miR-17-92 cluster are strongly induced after T-cell activation, down-regulated after clonal expansion, and further silenced during memory development. miR-17-92 promotes cell-cycle progression of effector CD8(+) T cells, and its expression is critical to the rapid ex ...[more]

PMID: 22665768

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