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Unknown,Transcriptomics,Genomics,Proteomics

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Transcriptome and methylome analyses of the nerd1-1 mutant

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Arabidopsis thaliana

SUBMITTER: FranM-CM-'ois ROUDIER

PROVIDER: E-GEOD-35346 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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NERD, a plant-specific GW protein, defines an additional RNAi-dependent chromatin-based pathway in Arabidopsis.

Pontier Dominique D Picart Claire C Roudier François F Garcia Damien D Lahmy Sylvie S Azevedo Jacinthe J Alart Emilie E Laudié Michèle M Karlowski Wojciech M WM Cooke Richard R Colot Vincent V Voinnet Olivier O Lagrange Thierry T

Molecular cell 20120830 1

In Arabidopsis, transcriptional gene silencing (TGS) can be triggered by 24 nt small-interfering RNAs (siRNAs) through the RNA-directed DNA methylation (RdDM) pathway. By functional analysis of NERD, a GW repeat- and PHD finger-containing protein, we demonstrate that Arabidopsis harbors a second siRNA-dependent DNA methylation pathway targeting a subset of nonconserved genomic loci. The activity of the NERD-dependent pathway differs from RdDM by the fact that it relies both on silencing-related ...[more]

PMID: 22940247

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