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Methylome analysis of Arabidopsis thaliana Col-0 primary root

ABSTRACT: DNA methylation profiling in Col-0 wild type primary root 2 biological replicates in dye-swap - MeDIP-chip

ORGANISM(S): Arabidopsis thaliana

SUBMITTER: FranM-CM-'ois ROUDIER

PROVIDER: E-GEOD-36750 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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MeDIP-HMM: genome-wide identification of distinct DNA methylation states from high-density tiling arrays.

Seifert Michael M Cortijo Sandra S Colomé-Tatché Maria M Johannes Frank F Roudier François F Colot Vincent V

Bioinformatics (Oxford, England) 20120917 22

<h4>Motivation</h4>Methylation of cytosines in DNA is an important epigenetic mechanism involved in transcriptional regulation and preservation of genome integrity in a wide range of eukaryotes. Immunoprecipitation of methylated DNA followed by hybridization to genomic tiling arrays (MeDIP-chip) is a cost-effective and sensitive method for methylome analyses. However, existing bioinformatics methods only enable a binary classification into unmethylated and methylated genomic regions, which limit ...[more]

PMID: 22989518

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