Unknown,Transcriptomics,Genomics,Proteomics

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Molecular sequelae of Nampt Inhibition in Human Multiple Myeloma cell line


ABSTRACT: Evaluation of specific coordinated pattern of transcriptional events consistent with anti-myeloma activity of FK866 (chemical Nampt inhibitor) 3 samples were analyzed using as control the untreated cells. Treated cells were cultured in presence of FK866 at concentration of 10nM for 6 and 24 hours.

ORGANISM(S): Homo sapiens

SUBMITTER: Michele Cea 

PROVIDER: E-GEOD-35414 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


Malignant cells have a higher nicotinamide adenine dinucleotide (NAD(+)) turnover rate than normal cells, making this biosynthetic pathway an attractive target for cancer treatment. Here we investigated the biologic role of a rate-limiting enzyme involved in NAD(+) synthesis, Nampt, in multiple myeloma (MM). Nampt-specific chemical inhibitor FK866 triggered cytotoxicity in MM cell lines and patient MM cells, but not normal donor as well as MM patients PBMCs. Importantly, FK866 in a dose-dependen  ...[more]

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