Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Michele Cea
PROVIDER: E-GEOD-35414 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Cea Michele M Cagnetta Antonia A Fulciniti Mariateresa M Tai Yu-Tzu YT Hideshima Teru T Chauhan Dharminder D Roccaro Aldo A Sacco Antonio A Calimeri Teresa T Cottini Francesca F Jakubikova Jana J Kong Sun-Young SY Patrone Franco F Nencioni Alessio A Gobbi Marco M Richardson Paul P Munshi Nikhil N Anderson Kenneth C KC
Blood 20120905 17
Malignant cells have a higher nicotinamide adenine dinucleotide (NAD(+)) turnover rate than normal cells, making this biosynthetic pathway an attractive target for cancer treatment. Here we investigated the biologic role of a rate-limiting enzyme involved in NAD(+) synthesis, Nampt, in multiple myeloma (MM). Nampt-specific chemical inhibitor FK866 triggered cytotoxicity in MM cell lines and patient MM cells, but not normal donor as well as MM patients PBMCs. Importantly, FK866 in a dose-dependen ...[more]