Proteomics

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Proteomic analysis of HMGA1-silencing

ABSTRACT: HMGA1 is a well-established oncogene and is a master regulator in breast cancer cells controlling the shift from a non-tumorigenic epithelial-like phenotype towards a highly aggressive mesenchymal-like one. In this work we compared HMGA1-silenced versus control MDA-MB-231 by means of a label free shotgun proteomics approach and crossed these data with DNA microarray expression profile obtained on the same cells. Resulting data were then filtered for genes linked to poor prognosis in breast cancer gene expression meta-datasets. This workflow allows us to establish a small molecular signature composed by 21 members with a prognostic value as regards overall-, recurrence free-, and distant metastasis free-survival in breast cancer.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Mario Oroshi  

LAB HEAD: Jacek R Wisniewski

PROVIDER: PXD002032 | Pride | 2018-10-17

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
20120522_Orbi3_JRW_SA_88_L1.RAW Raw
20120522_Orbi3_JRW_SA_88_L2.RAW Raw
20120522_Orbi3_JRW_SA_88_T1.RAW Raw
20120522_Orbi3_JRW_SA_88_T2.RAW Raw
20120522_Orbi3_JRW_SA_89_L1.RAW Raw
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Publications

Translating Proteomic Into Functional Data: An High Mobility Group A1 (HMGA1) Proteomic Signature Has Prognostic Value in Breast Cancer.

Maurizio Elisa E   Wiśniewski Jacek R JR   Ciani Yari Y   Amato Angela A   Arnoldo Laura L   Penzo Carlotta C   Pegoraro Silvia S   Giancotti Vincenzo V   Zambelli Alberto A   Piazza Silvano S   Manfioletti Guidalberto G   Sgarra Riccardo R  

Molecular & cellular proteomics : MCP 20151102 1

Cancer is a very heterogeneous disease, and biological variability adds a further level of complexity, thus limiting the ability to identify new genes involved in cancer development. Oncogenes whose expression levels control cell aggressiveness are very useful for developing cellular models that permit differential expression screenings in isogenic contexts. HMGA1 protein has this unique property because it is a master regulator in breast cancer cells that control the transition from a nontumori  ...[more]

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