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CGH analysis of AG-haESCs (androgenetic haploid embryonic stem cells)

ABSTRACT: The genomic DNA sample of AG-haESCs were compared to the C57BL/6J male mouse kidney by comparative genomic hybridization. The data confirmed that the haploid cells sustained genome integrity. The analysis was performed on a NimbleGen Mouse CGH 3x720K Whole-Genome Tiling Array to analyse the copy number variations in AG-haESCs, and the genomic DNA of C57BL/6J male mouse kidney was used as control, which had the same background with haploid ESCs.

ORGANISM(S): Mus musculus

SUBMITTER: Linyu Shi 

PROVIDER: E-GEOD-35786 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Generation of genetically modified mice by oocyte injection of androgenetic haploid embryonic stem cells.

Yang Hui H   Shi Linyu L   Wang Bang-An BA   Liang Dan D   Zhong Cuiqing C   Liu Wei W   Nie Yongzhan Y   Liu Jie J   Zhao Jing J   Gao Xiang X   Li Dangsheng D   Xu Guo-Liang GL   Li Jinsong J  

Cell 20120401 3

Haploid cells are amenable for genetic analysis. Recent success in the derivation of mouse haploid embryonic stem cells (haESCs) via parthenogenesis has enabled genetic screening in mammalian cells. However, successful generation of live animals from these haESCs, which is needed to extend the genetic analysis to the organism level, has not been achieved. Here, we report the derivation of haESCs from androgenetic blastocysts. These cells, designated as AG-haESCs, partially maintain paternal impr  ...[more]

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