Unknown,Transcriptomics,Genomics,Proteomics

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Leukocyte gene expression in rhesus macaques reared under different conditions

ABSTRACT: Gene expression profiling was carried out on peripheral blood mononuclear cell mRNA samples collected from 4 mo old rhesus macaques subject to maternal rearing, peer rearing, or surrogate peer rearing. The primary research question is whether gene expression differs as a function of early rearing conditions. Gene expression profiling was carried out on peripheral blood mononuclear cell mRNA samples collected from 4 mo old rhesus macaques subject to maternal rearing, peer rearing, or surrogate peer rearing. The primary research question is whether gene expression differs as a function of early rearing conditions.

ORGANISM(S): Macaca mulatta

SUBMITTER: Steve Cole 

PROVIDER: E-GEOD-35850 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Transcriptional modulation of the developing immune system by early life social adversity.

Cole Steven W SW   Conti Gabriella G   Arevalo Jesusa M G JM   Ruggiero Angela M AM   Heckman James J JJ   Suomi Stephen J SJ  

Proceedings of the National Academy of Sciences of the United States of America 20121126 50

To identify molecular mechanisms by which early life social conditions might influence adult risk of disease in rhesus macaques (Macaca mulatta), we analyze changes in basal leukocyte gene expression profiles in 4-mo-old animals reared under adverse social conditions. Compared with the basal condition of maternal rearing (MR), leukocytes from peer-reared (PR) animals and PR animals provided with an inanimate surrogate mother (surrogate/peer reared, SPR) show enhanced expression of genes involved  ...[more]

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