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Human lung adenocarcinoma DNA methylation profiling by MSNP

ABSTRACT: Lung adenocarcinoma’s genomic alterations exhibit vast variation. Lung adenocarcinoma also has previously described intrinsic gene expression subtypes (Hayes et al. 2006, PMID: 17075127). This study detect global methylation differences among gene expression subtypes. These specimens were also assayed for genomewide transcription in GSE26939 and copy number in GSE36363. 33 tumor samples and 10 normal samples were quantified for DNA methylation by MSNP (Yuan et al, PMID: 16585166) using Affymetrix SNP 250K_StyI microarrays.

ORGANISM(S): Homo sapiens

SUBMITTER: Matthew Wilkerson

PROVIDER: E-GEOD-36438 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Differential pathogenesis of lung adenocarcinoma subtypes involving sequence mutations, copy number, chromosomal instability, and methylation.

Wilkerson Matthew D MD Yin Xiaoying X Walter Vonn V Zhao Ni N Cabanski Christopher R CR Hayward Michele C MC Miller C Ryan CR Socinski Mark A MA Parsons Alden M AM Thorne Leigh B LB Haithcock Benjamin E BE Veeramachaneni Nirmal K NK Funkhouser William K WK Randell Scott H SH Bernard Philip S PS Perou Charles M CM Hayes D Neil DN

PloS one 20120510 5

<h4>Background</h4>Lung adenocarcinoma (LAD) has extreme genetic variation among patients, which is currently not well understood, limiting progress in therapy development and research. LAD intrinsic molecular subtypes are a validated stratification of naturally-occurring gene expression patterns and encompass different functional pathways and patient outcomes. Patients may have incurred different mutations and alterations that led to the different subtypes. We hypothesized that the LAD molecula ...[more]

PMID: 22590557

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2011-05-05 | E-GEOD-29071 | biostudies-arrayexpress

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2013-03-01 | E-GEOD-44757 | biostudies-arrayexpress

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2011-10-25 | E-GEOD-26758 | biostudies-arrayexpress

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2013-07-30 | E-GEOD-42723 | biostudies-arrayexpress

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