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Combined microRNA/mRNA transcriptome analysis reveals angiogenic microRNAs-genes pathway of human late endothelial precursor cells.

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Tse-Shun Huang

PROVIDER: E-GEOD-37046 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Deficiency of the microRNA-31-microRNA-720 pathway in the plasma and endothelial progenitor cells from patients with coronary artery disease.

Wang Hsei-Wei HW Huang Tse-Shun TS Lo Hung-Hao HH Huang Po-Hsun PH Lin Chih-Ching CC Chang Shing-Jyh SJ Liao Ko-Hsun KH Tsai Chin-Han CH Chan Chia-Hao CH Tsai Cheng-Fong CF Cheng Yi-Chieh YC Chiu Ya-Ling YL Tsai Tsung-Neng TN Cheng Cheng-Chung CC Cheng Shu-Meng SM

Arteriosclerosis, thrombosis, and vascular biology 20140220 4

<h4>Objective</h4>Defects in angiogenesis/vasculogenesis or vessel repair are major complications of coronary artery disease (CAD). Endothelial progenitor cells (EPCs) play a fundamental role in postnatal vascular repair and CAD. The role of microRNAs in CAD pathogenesis and their potential as biomarkers remain to be elucidated.<h4>Approach and results</h4>MicroRNA-31 (miR-31) level in both the plasma and EPCs of patients with CAD is found lower. miR-31 regulates EPC activities by targeting FAT ...[more]

PMID: 24558106

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