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Gene expression profile of TARDBP in hepatocellular carcinoma cell line (SK-Hep1)

ABSTRACT: TARDBP is TARDBP (TDP-43) is a DNA/RNA binding protein and was mutated in human amyotrophic lateral sclerosis (ALS). However, its function in human cancer has not been fully identified, yet.Thus, We carried out microarray to investigate the down-stream target genes of TARDBP after silencing TARDBP in liver cancer cell SK-Hep1. To identify the role of TARDBP in hepatocellular carcinoma cell line, we performed microarray after knocking down TARDBP in hepatocellular carcinoma cell line (3 siLuc, 3 siTARDBP)

ORGANISM(S): Homo sapiens

SUBMITTER: Yun-Yong Park

PROVIDER: E-GEOD-37640 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Tat-activating regulatory DNA-binding protein regulates glycolysis in hepatocellular carcinoma by regulating the platelet isoform of phosphofructokinase through microRNA 520.

Park Yun-Yong YY Kim Sang-Bae SB Han Hee Dong HD Sohn Bo Hwa BH Kim Ji Hoon JH Liang Jiyong J Lu Yiling Y Rodriguez-Aguayo Cristian C Lopez-Berestein Gabriel G Mills Gordon B GB Sood Anil K AK Lee Ju-Seog JS

Hepatology (Baltimore, Md.) 20130515 1

<h4>Unlabelled</h4>Metabolic changes are common features of many cancer cells and are frequently associated with the clinical outcome of patients with various cancers, including hepatocellular carcinoma (HCC). Thus, aberrant metabolic pathways in cancer cells are attractive targets for cancer therapy. However, our understanding of cancer-specific regulatory mechanisms of cell metabolism is still very limited. We found that Tat-activating regulatory DNA-binding protein (TARDBP) is a novel regulat ...[more]

PMID: 23389994

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