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Differences in gene expression between murine Fnip1-null pre-B cells and wild type pre-B cells.

ABSTRACT: Analysis of gene expression in FACs-sorted pre-B cells derived from Fnip1-null and normal wildtype littermate mice. 3 arrays from 3 different mice per genotype were utilized to generate the expression data (mouse WG-6 v.2.0 beadchip (Illumina Inc, San Diego CA)) and statistics. P-values are shown. Total RNAs were isolated from sorted B220+CD43+ cell from Fnip1-/- and WT mice (n=3)

ORGANISM(S): Mus musculus

SUBMITTER: Brian Iritani

PROVIDER: E-GEOD-37687 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Differences in gene expression between murine Fnip1-null pre-B cells and wild type pre-B cells.

Project description:Analysis of gene expression in FACs-sorted pre-B cells derived from Fnip1-null and normal wildtype littermate mice. 3 arrays from 3 different mice per genotype were utilized to generate the expression data (mouse WG-6 v.2.0 beadchip (Illumina Inc, San Diego CA)) and statistics. P-values are shown.

2012-05-02 | GSE37687 | GEO

BTG1 and BTG2 Regulate B Linege Commitment by Modulation of EBF1 Activity

Project description:The human BTG1 and BTG2 genes are targeted by genetic alterations in hematological malignancies. In this study we examined the unique and overlapping functions of Btg1 and Btg2 in mouse B cell development. Mice deficient for Btg1 and Btg2 displayed the strongest phenotype with a decrease in B cell numbers in bone marrow due to impaired B cell commitment and immature B cell differentiation. To determine the underlying mechanism, microarray expression analyis was performed on early (B220+ CD43+) and late (B220+ CD43-) B cells of WT and Btg1;Btg2 dKO mice. Total RNA obtained from sorted B220+ CD43+ ( Hardy fractions ABC) and B220+ CD43- (Hardy fractions DEF) BM cells of WT and Btg1-/-;Btg2-/- mice. In total 4 samples were analyzed and no replicates were included.

2014-03-19 | E-GEOD-55997 | biostudies-arrayexpress

Transcriptome Analysis of IL-33-Deficient Early Developing B Cells

Project description:We identified that IL-33 is expressed in pro-B (B220+ IgM- CD19+ CD43+) and large pre-B cells (B220+ IgM- CD19+ CD43- FSC-Ahi SSC-Ahi) in mice. We assessed for IL-33-dependent gene expression differences in these B cell stages by performing bulk RNA-sequencing of FACS-purified pro-B and large pre-B cells from WT and IL-33-deficient 8 week old adult, naive female mice.

2019-07-04 | GSE132123 | GEO

BTG1 and BTG2 Regulate B Linege Commitment by Modulation of EBF1 Activity

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Gene expression profile of Cnot3(+/+) & Cnot3 (∆/∆) pro-B cells

Project description:To study the role Cnot3 in early B cells development, RNASeq analysis of pro-B cells (B220+ and CD43+) was performed in tamoxifen treated Cnot3(fl/fl) RERTCre and Cnot3+/+;RERTCre mice.

2016-11-21 | GSE87635 | GEO

Effect of knockout of UPF1 on gene expression during differentiation in early LPre-B stage.

Project description:To investigate the role of UPF1 in the early Lpre-B cells (Fixable Viability Dye-, CD19+, B220+, sIgM-, CD43+, FSChi, CD2-), we isolated early Lpre-B cells from bone marrow derived from control or Upf1-cKO mice.

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microRNA profiling of fetal liver and adult bone marrow pro-B cells

Project description:We used the NanoString mouse nCounter miRNA expression platform to compare the miRNA expression profiles of pro-B cells sorted from fetal liver and adult bone marrow in order to gain insight into changes in miRNA expression during B cell ontogeny. Fetal liver and adult bone marrow cells were harvested and FACS sorted for pro-B cells (B220+CD43+IgM-veCD19+CD24+). Total RNA was extracted and used for sample preparation and hybridization per manufacturer's instructions.

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Expression data from murine bone marrow-resident plasma cells and spleen mature follicular B cells

Project description:CD138+ B220- plasma cells were sorted from bone marrow and B220+ CD23+ mature follicular B cells were sorted from the spleens. Plasma cells were sorted from C57BL/6 mice 7 days after boosting with antigen, with mice first primed with an i.p. injection of KLH/IFA followed by boost at day 21 with KLH/PBS i.p. Mature B cells were sorted from antigen-naïve C57BL/6 mice. We compared expression profiles of plasma cells and mature B cells to identify differentially expressed transcripts.

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