Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Emilie Besnard
PROVIDER: E-GEOD-37757 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Nature structural & molecular biology 20120701 8
DNA replication is highly regulated, ensuring faithful inheritance of genetic information through each cell cycle. In metazoans, this process is initiated at many thousands of DNA replication origins whose cell type-specific distribution and usage are poorly understood. We exhaustively mapped the genome-wide location of replication origins in human cells using deep sequencing of short nascent strands and identified ten times more origin positions than we expected; most of these positions were co ...[more]