Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Meinrad Busslinger
PROVIDER: E-GEOD-38046 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Revilla-I-Domingo Roger R Bilic Ivan I Vilagos Bojan B Tagoh Hiromi H Ebert Anja A Tamir Ido M IM Smeenk Leonie L Trupke Johanna J Sommer Andreas A Jaritz Markus M Busslinger Meinrad M
The EMBO journal 20120605 14
Pax5 controls the identity and development of B cells by repressing lineage-inappropriate genes and activating B-cell-specific genes. Here, we used genome-wide approaches to identify Pax5 target genes in pro-B and mature B cells. In these cell types, Pax5 bound to 40% of the cis-regulatory elements defined by mapping DNase I hypersensitive (DHS) sites, transcription start sites and histone modifications. Although Pax5 bound to 8000 target genes, it regulated only 4% of them in pro-B and mature B ...[more]