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Transcription profiling of S. cerevisiae wild type and amino-terminus mutant histone H2B (HTB1) strains

ABSTRACT: Histone H2B was mutated to give H2B^3-32, H2B K->G, H2B^3-37, and H2B^30-37. Total RNA from three replicate cultures of wild-type and mutant was isolated and the expression profiles were determined using Affymetrix arrays. Comparisons between the sample groups allow the identification of genes regulated by H2B HBR domain. Experiment Overall Design: mutants compared to wild-type, 3 replicates Experiment Overall Design: This reference Series links data in the following related Series: Experiment Overall Design: GSE3802 Histone H2B^3-32 Experiment Overall Design: GSE3803 Histone H2B K->G Experiment Overall Design: GSE3804 Histone H2B^3-37 Experiment Overall Design: GSE3805 Histone H2B^3-37

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: John Wyrick 

PROVIDER: E-GEOD-3806 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Deciphering the roles of the histone H2B N-terminal domain in genome-wide transcription.

Parra Michael A MA   Kerr David D   Fahy Deirdre D   Pouchnik Derek J DJ   Wyrick John J JJ  

Molecular and cellular biology 20060501 10

Histone N-terminal domains are frequent targets of posttranslational modifications. Multiple acetylated lysine residues have been identified in the N-terminal domain of H2B (K6, K11, K16, K17, K21, and K22), but little is known about how these modifications regulate transcription. We systematically mutated the N-terminal domain of histone H2B, both at known sites of lysine acetylation and elsewhere, and characterized the resulting changes in genome-wide expression in each mutant strain. Our resu  ...[more]

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