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Sex and aging effect on skeletal muscle transcriptome in humans

ABSTRACT: The aim of this investigation was to develop a global view of muscle transcriptional differences between older men and women and with aging for each sex. Muscle biopsies were obtained from the biceps brachii of young (age 19~28yrs) and older (age 65~76 yrs) men (7 young, 4 older) and women (7 young, 4 older). Total RNA was extracted and gene expression profiling was performed using the Affymetrix Human Genome U133 Plus 2 chip.

ORGANISM(S): Homo sapiens

SUBMITTER: GORDON PAUL

PROVIDER: E-GEOD-38718 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Microarray analysis reveals novel features of the muscle aging process in men and women.

Liu Dongmei D Sartor Maureen A MA Nader Gustavo A GA Pistilli Emidio E EE Tanton Leah L Lilly Charles C Gutmann Laurie L IglayReger Heidi B HB Visich Paul S PS Hoffman Eric P EP Gordon Paul M PM

The journals of gerontology. Series A, Biological sciences and medical sciences 20130215 9

To develop a global view of muscle transcriptional differences between older men and women and sex-specific aging, we obtained muscle biopsies from the biceps brachii of young and older men and women and profiled the whole-genome gene expression using microarray. A logistic regression-based method in combination with an intensity-based Bayesian moderated t test was used to identify significant sex- and aging-related gene functional groups. Our analysis revealed extensive sex differences in the m ...[more]

PMID: 23418191

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