Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Marc Mendillo
PROVIDER: E-GEOD-38901 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Mendillo Marc L ML Santagata Sandro S Koeva Martina M Bell George W GW Hu Rong R Tamimi Rulla M RM Fraenkel Ernest E Ince Tan A TA Whitesell Luke L Lindquist Susan S
Cell 20120801 3
Heat-Shock Factor 1 (HSF1), master regulator of the heat-shock response, facilitates malignant transformation, cancer cell survival, and proliferation in model systems. The common assumption is that these effects are mediated through regulation of heat-shock protein (HSP) expression. However, the transcriptional network that HSF1 coordinates directly in malignancy and its relationship to the heat-shock response have never been defined. By comparing cells with high and low malignant potential alo ...[more]