HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers [ChIP-Seq]

ABSTRACT: Heat-Shock Factor 1 (HSF1), master regulator of the heat-shock response, facilitates malignant transformation, cancer cell survival and proliferation in model systems. The common assumption is that these effects are mediated through regulation of heat-shock protein (HSP) expression. However, the transcriptional network that HSF1 coordinates directly in malignancy and its relationship to the heat-shock response have never been defined. By comparing cells with high and low malignant potential alongside their non-transformed counterparts, we identify an HSF1-regulated transcriptional program specific to highly malignant cells and distinct from heat shock. Cancer-specific genes in this program support oncogenic processes: cell-cycle regulation, signaling, metabolism, adhesion and translation.

ORGANISM(S): Homo sapiens

SUBMITTER: Marc Mendillo 

PROVIDER: E-GEOD-38901 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress