RNA-seq of estrogen (E2) induced changes of mRNA expression in Sus scrofa male and female blastocysts derived from embryonic day 10
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina HiSeq 2000
ORGANISM(S): Sus scrofa
SUBMITTER: Stefan Bauersachs
PROVIDER: E-MTAB-6263 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Exposure of pregnant sows to low doses of estradiol-17β impacts on the transcriptome of the endometrium and the female preimplantation embryos†.
Flöter Veronika L VL Bauersachs Stefan S Fürst Rainer W RW Krebs Stefan S Blum Helmut H Reichenbach Myriam M Ulbrich Susanne E SE
Biology of reproduction 20190301 3
Maternal exposure to estrogens can induce long-term adverse effects in the offspring. The epigenetic programming may start as early as the period of preimplantation development. We analyzed the effects of gestational estradiol-17β (E2) exposure with two distinct low doses, corresponding to the acceptable daily intake "ADI" and close to the no-observed-effect level "NOEL", and a high dose (0.05, 10, and 1000 μg E2/kg body weight daily, respectively). The E2 doses were orally applied to sows from ...[more]
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