Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Wenbin Wei
PROVIDER: E-GEOD-39826 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Port Rebecca J RJ Pinheiro-Maia Sonia S Hu Chunfang C Arrand John R JR Wei Wenbin W Young Lawrence S LS Dawson Christopher W CW
The Journal of pathology 20131101 3
Nasopharyngeal carcinoma (NPC) is a cancer common in southern China and South East Asia that is causally linked to Epstein-Barr virus (EBV) infection. Here, we demonstrate that NPC displays frequent dysregulation of the Hedgehog (HH) pathway, a pathway implicated in the maintenance of stem cells, but whose aberrant activation in adult tissues can lead to cancer. Using authentic EBV-positive carcinoma-derived cell lines and nasopharyngeal epithelial cell lines latently infected with EBV as models ...[more]