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Tissue and blood microRNA array profiles of colorectal cancer patients

ABSTRACT: microRNAs (miRNAs) are short, non-coding RNA molecules that act as regulators of gene expression. Circulating blood miRNAs offer great potential as cancer biomarkers. The objective of the study was to correlate the differential expression of miRNAs in tissue and blood in the identification of biomarkers for early detection of colorectal cancer (CRC). miRNA biomarker discovery via miRNA array profiling using paired cancer tissues (n = 30) and blood samples (CRC, n = 42; control, n = 18).

ORGANISM(S): Homo sapiens

SUBMITTER: Yong Lin

PROVIDER: E-GEOD-39845 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Potentiality of a triple microRNA classifier: miR-193a-3p, miR-23a and miR-338-5p for early detection of colorectal cancer.

Yong Fung Lin FL Law Chee Wei CW Wang Chee Woon CW

BMC cancer 20130608

<h4>Background</h4>MicroRNAs (miRNAs) are short, non-coding RNA molecules that act as regulators of gene expression. Circulating blood miRNAs offer great potential as cancer biomarkers. The objective of this study was to correlate the differential expression of miRNAs in tissue and blood in the identification of biomarkers for early detection of colorectal cancer (CRC).<h4>Methods</h4>The study was divided into two phases: (I) Marker discovery by miRNA microarray using paired cancer tissues (n = ...[more]

PMID: 23758639

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