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Functional Roles of Hdac1/2 in lung development

ABSTRACT: Hdac1/2 are important epigenetic factors, yet their functional roles in specific tissues inluding lung is not determined. We used the conditional knockout model of Hdac1/2 to determine their roles in lung development. To explore the genes that are regulated by Hdac1/2 during lung development, we performed microarray analysis of Shhcre control and Hdac1/2DKO lungs at E11.5 embryos.

ORGANISM(S): Mus musculus

SUBMITTER: Yi Wang

PROVIDER: E-GEOD-39946 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Development and regeneration of Sox2+ endoderm progenitors are regulated by a Hdac1/2-Bmp4/Rb1 regulatory pathway.

Wang Yi Y Tian Ying Y Morley Michael P MP Lu Min M MM Demayo Francesco J FJ Olson Eric N EN Morrisey Edward E EE

Developmental cell 20130201 4

The mechanisms that govern the maintenance and differentiation of tissue-specific progenitors in development and tissue regeneration are poorly understood. We show that development of Sox2+ progenitors in the lung endoderm is regulated by histone deacetylases 1 and 2 (Hdac1/2). Hdac1/2 deficiency leads to a loss of Sox2 expression and a block in proximal airway development. This is mediated in part by derepression of Bmp4 and the tumor suppressor Rb1, which are direct transcriptional targets of ...[more]

PMID: 23449471

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