Unknown,Transcriptomics,Genomics,Proteomics

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IL-2 induced gene expression changes in Kit225 human leukemia cell lines


ABSTRACT: Identify IL-2 mediated genes in Kit225 cells. IL-2 withdrawn cells were treated with IL-2 or left untreated for 3 hours and then subjected to gene expression microarray analysis.

ORGANISM(S): Homo sapiens

SUBMITTER: Zsuzsanna Nagy 

PROVIDER: E-GEOD-40618 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Genome wide mapping reveals PDE4B as an IL-2 induced STAT5 target gene in activated human PBMCs and lymphoid cancer cells.

Nagy Zsuzsanna S ZS   Ross Jeremy A JA   Rodriguez Georgialina G   Balint Balint L BL   Szeles Lajos L   Nagy Laszlo L   Kirken Robert A RA  

PloS one 20130225 2


IL-2 is the primary growth factor for promoting survival and proliferation of activated T cells that occurs following engagement of the Janus Kinase (JAK)1-3/and Signal Transducer and Activator of Transcription (STAT) 5 signaling pathway. STAT5 has two isoforms: STAT5A and STAT5B (commonly referred to as STAT5) which, in T cells, play redundant roles transcribing cell cycle and survival genes. As such, inhibition of STAT5 by a variety of mechanisms can rapidly induce apoptosis in certain lymphoi  ...[more]

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