Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

PGN induced transcriptional changes in human neonatal neutrophils

ABSTRACT: We have employed whole genome microarray expression profiling to identify genes differentially expressed in cord blood purified neutrophils after a short-term exposure to peptidoglycan (PGN). PGN induced gene expressions of neonatal neutrophils were measured at 4 hours. Three biological replicates were performed for each treatment group.

ORGANISM(S): Homo sapiens

SUBMITTER: Kathy Chan

PROVIDER: E-GEOD-40636 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Expression profile of cord blood neutrophils and dysregulation of HSPA1A and OLR1 upon challenge by bacterial peptidoglycan.

Fong Oi Ning ON Chan Kathy Yuen Yee KY Leung Kam Tong KT Lam Hugh Simon HS Cheung Hon Ming HM Leung Tak Yeung TY Li Karen K Ng Pak Cheung PC

Journal of leukocyte biology 20130828 1

In newborn infants, the innate cellular system plays a crucial role in the first line of defense against pathogens. Neutrophils are the most abundant leukocytes, and their response to the commonly encountered nosocomial bacterial (Gram positive) infection in newborns remains largely unclear. In this study, a genome-wide expression array analysis was performed on CB neutrophils after challenge by PGN in vitro and compared with neutrophils in CTL cultures without PGN. We investigated responses of ...[more]

PMID: 23986550

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Dataset Information

PGN induced transcriptional changes in human neonatal neutrophils

Publications

Expression profile of cord blood neutrophils and dysregulation of HSPA1A and OLR1 upon challenge by bacterial peptidoglycan.

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