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Bowel expression profiles of infants with gastrointestinal conditions

ABSTRACT: We have employed whole genome microarray expression profiling to identify genes differentially expressed in neonatal bowel tissues of different gastrointestinal conditions. Bowel tissues were collected from infants who underwent surgery treatment for necrotising enterocolitis (NEC) and spontaneous intestinal perforation (SIP). Infants with other non-inflammatory, congenital intestinal conditions were employed as the Surgical-Control. Differential whole genome microarray analysis was performed.

ORGANISM(S): Homo sapiens

SUBMITTER: Kathy Chan

PROVIDER: E-GEOD-46619 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genome-wide expression profiles of necrotizing enterocolitis versus spontaneous intestinal perforation in human intestinal tissues: dysregulation of functional pathways.

Chan Kathy Yuen Yee KY Leung Kam Tong KT Tam Yuk Him YH Lam Hugh Simon HS Cheung Hon Ming HM Ma Terence Ping Yuen TP Lee Kim Hung KH To Ka Fai KF Li Karen K Ng Pak Cheung PC

Annals of surgery 20141201 6

<h4>Objective</h4>To provide a comprehensive database of gene regulation and compare differentially regulated molecular networks in human tissues of necrotizing enterocolitis (NEC) and spontaneous intestinal perforation (SIP).<h4>Background</h4>Both NEC and SIP are devastating surgical emergencies associated with high morbidity and mortality in preterm infants. Their pathophysiology and molecular mechanisms remain unclear.<h4>Methods</h4>Differential whole genome microarray analysis was performe ...[more]

PMID: 24368664

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