Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Damian Roqueiro
PROVIDER: E-GEOD-40725 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Yin Ping P Roqueiro Damian D Huang Lei L Owen Jonas K JK Xie Anna A Navarro Antonia A Monsivais Diana D Coon John S JS Kim J Julie JJ Dai Yang Y Bulun Serdar E SE
PloS one 20120117 1
<h4>Background</h4>Progesterone, via its nuclear receptor (PR), exerts an overall tumorigenic effect on both uterine fibroid (leiomyoma) and breast cancer tissues, whereas the antiprogestin RU486 inhibits growth of these tissues through an unknown mechanism. Here, we determined the interaction between common or cell-specific genome-wide binding sites of PR and mRNA expression in RU486-treated uterine leiomyoma and breast cancer cells.<h4>Principal findings</h4>ChIP-sequencing revealed 31,457 and ...[more]