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Transcription profiling of mouse pluripotet embyonal carcinoma cells

ABSTRACT: Investigation of very early events required for initiating differentiation of pluripotent embryonal carcinoma cells - the effect of cell aggregation on gene expression. Experiment Overall Design: this experiment include 4 samples and 24 replicates

ORGANISM(S): Mus musculus

SUBMITTER: OGIC Info Ontario Genomics Innovation Centre (OGIC)

PROVIDER: E-GEOD-4085 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The Effect of Cell Aggregation on Gene Expression of Pluripotent Embryonal Carcinoma Cells

Project description:Investigation of very early events required for initiating differentiation of pluripotent embryonal carcinoma cells - the effect of cell aggregation on gene expression. Keywords: cell aggregation

2006-01-24 | GSE4085 | GEO

Transcription profiling of mouse sorted bone marrow samples to determine genes implicated in hematopoetic stem cell identity

Project description:Gene expression profiles of sorted bone marrow samples to determine genes implicated in hematopoetic stem cell identity. Experiment Overall Design: this experiment include 6 samples and 32 replicates

2008-06-12 | E-GEOD-3234 | biostudies-arrayexpress

Transcription profiling of human hematopoietic stem cells originating from different stages of ontogeny

Project description:Investigation of human hematopoietic stem cells gene expression patterns originating from different stages of ontogeny including fetal blood, cord blood, bone marrow, and mobilized peripheral blood in Lin-CD34+CD38- versus Lin-CD34+CD38+ populations. Experiment Overall Design: this experiment include 7 samples and 42 replicates

2008-06-12 | E-GEOD-3823 | biostudies-arrayexpress

Transcription profiling of human and mouse first passage vs. primary retinal sphere cells

Project description:The pigmented portion of ciliary epithelium in the adult mammalian eye harbors mitotically quiescent retinal sphere cells, which are capable of self-renewal and differentiating into retinal neurons when assayed in vitro; however, very little is known about the molecular mechanism controlling the proliferation and differentiation of these adult retinal stem cells or their molecular resemblance to mutipotent stem/progenitor cells during early eye development. This experiment studies the gene expression of first passage and primary human and mouse retinal sphere cells. Experiment Overall Design: this experiment include 4 samples and 12 replicates

2008-06-12 | E-GEOD-3791 | biostudies-arrayexpress

Transcription profiling of mouse undifferentiated and differentiated mammospheres isolated from FVB animaks

Project description:Mammary gland cells were isolated from 5-8 week old FVB mice and allowed to proliferate as undifferentiated mammospheres in the presence of growth factors (bFGF and EGF). Comparison of the gene expression profiles of undifferentiated mammospheres vs. mammospheres that were allowed to differentiate for 6 days by the removal of growth factors will help to identify genes that are implicated in the maintenance of the mammary gland stem cell compartment. Experiment Overall Design: this experiment include 2 samples and 12 replicates

2008-06-12 | E-GEOD-3777 | biostudies-arrayexpress

Transcription profiling of mouse mammary epithelial stem cells and differentiated derivatives

Project description:Gene Expression Profiling of Murine Mammary Stem Cells and Differentiated Derivatives.

2007-12-15 | E-GEOD-3711 | biostudies-arrayexpress

Transcription profiling of mouse pRb null primary myoblasts and myotubes will provide a global picture of the downstream targets of pRb transcriptional regulation in relation to cell cycle control, apoptosis inhibition, and muscle differentiation

Project description:Satellite cells play an important role in post-natal growth and regeneration of skeletal muscle. They can be defined as a population adult muscle stem cells based on their self renewal capability and ability to differentiate into skeletal muscle fibers. Functional Retinoblastoma protein (pRb) is essential for the process of skeletal muscle differentiation in satellite cell derived primary myoblasts. Furthermore, the biochemical function of pRb is largely associated with its ability to interact with chromatin modifying factors such as histone deacetylases (HDACs) and histone methyltransferases thus inhibiting transcription of target gene promoters. Hence, expression profiling of pRb null primary myoblasts and myotubes will provide a global picture of the downstream targets of pRb transcriptional regulation in relation to cell cycle control, apoptosis inhibition, and muscle differentiation. Experiment Overall Design: This experiment includes 4 samples with 3 replicates each on 2 platforms for a total of 24 Samples.

2008-04-08 | E-GEOD-10428 | biostudies-arrayexpress

Transcription profiling of human megakaryotic and fibroblast cell lines that have been transduced with either Smad7 recombinant retroviral vector vs control

Project description:Smad7 is a member of the TGF-B superfamily that plays a signigicant role in fate determination of hematopoietic stem cells. This experiment compares expression between megakaryotic and fibroblast cell lines that have been transduced with either Smad7 recombinant retroviral vector or retroviral vector alone. Experiment Overall Design: this experiment include 4 samples and 30 replicates

2008-06-12 | E-GEOD-3771 | biostudies-arrayexpress

Transcription profiling of human embryonic skeletal myoblasts

Project description:Skeletal muscle cells (myoblasts - human fetal cells from 17 week old embryo) Experiment Overall Design: this experiment include 1 samples and 6 replicates

2008-06-12 | E-GEOD-3230 | biostudies-arrayexpress

Transcription profiling of mouse osteoblast differentiation - time series

Project description:Differentiation Time Course; examination of osteoblast differentation by comparing cells exposed to growth factors with ctrl cells. Experiment Overall Design: this experiment include 7 samples and 42 replicates

2008-06-12 | E-GEOD-3792 | biostudies-arrayexpress

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