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Transcription profiling of mouse mammary epithelial stem cells and differentiated derivatives

ABSTRACT: Gene Expression Profiling of Murine Mammary Stem Cells and Differentiated Derivatives.

ORGANISM(S): Mus musculus

SUBMITTER: Ontario Genomics Innovation Centre (OGIC)

PROVIDER: E-GEOD-3711 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Purification and unique properties of mammary epithelial stem cells.

Stingl John J Eirew Peter P Ricketson Ian I Shackleton Mark M Vaillant François F Choi David D Li Haiyan I HI Eaves Connie J CJ

Nature 20060104 7079

Elucidation of the cellular and molecular mechanisms that maintain mammary epithelial tissue integrity is of broad interest and paramount to the design of more effective treatments for breast cancer. Evidence from both in vitro and in vivo experiments suggests that mammary cell differentiation is a hierarchical process originating in an uncommitted stem cell with self-renewal potential. However, analysis of the properties and regulation of mammary stem cells has been limited by a lack of methods ...[more]

PMID: 16395311

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