Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
DISEASE(S): arrhythmias and right ventricular dysfunction
SUBMITTER: Henning Witt
PROVIDER: E-GEOD-4120 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Circulation 20061009 17
<h4>Background</h4>Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited disorder that causes sudden death and right ventricular heart failure in the young. Clinical data suggest that competitive sports may provoke ARVC in susceptible persons. Genetically, loss-of-function mutations in desmosomal proteins (plakophilin, desmoplakin, or plakoglobin) have been associated with ARVC. To test the hypothesis that reduced desmosomal protein expression causes ARVC, we studied the cardiac ...[more]