Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Acute Stress Induced Increase in Histone H3 Lys 9 Trimetylation in Rat Hippocampus

ABSTRACT: We utilized ChIP Seq to examine the the genomic localization of the increase in H3K9 trimethylation we had previously observed in the hippocampus as a consequence of acute restraint stress in rats (Hunter et. al PNAS 2009). Rats were restrained for 30 minutes, allowed to recover for 1 hour and then sacrificed and their hippocampi extracted and processed for H3K9me3 ChIP using the Cell Signalling H3K9me3 antibody.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Richard Hunter

PROVIDER: E-GEOD-41217 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Acute stress and hippocampal histone H3 lysine 9 trimethylation, a retrotransposon silencing response.

Hunter Richard G RG Murakami Gen G Dewell Scott S Seligsohn Ma'ayan M Baker Miriam E R ME Datson Nicole A NA McEwen Bruce S BS Pfaff Donald W DW

Proceedings of the National Academy of Sciences of the United States of America 20121004 43

The hippocampus is a highly plastic brain region particularly susceptible to the effects of environmental stress; it also shows dynamic changes in epigenetic marks in response to stress and learning. We have previously shown that, in the rat, acute (30 min) restraint stress induces a substantial, regionally specific, increase in hippocampal levels of the repressive histone H3 lysine 9 trimethylation (H3K9me3). Because of the large magnitude of this effect and the fact that stress can induce the ...[more]

PMID: 23043114

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Dataset Information

Acute Stress Induced Increase in Histone H3 Lys 9 Trimetylation in Rat Hippocampus

Publications

Acute stress and hippocampal histone H3 lysine 9 trimethylation, a retrotransposon silencing response.

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