Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Fernando Camargo
PROVIDER: E-GEOD-41506 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Nature 20121125 7430
A remarkable feature of regenerative processes is their ability to halt proliferation once an organ's structure has been restored. The Wnt signalling pathway is the major driving force for homeostatic self-renewal and regeneration in the mammalian intestine. However, the mechanisms that counterbalance Wnt-driven proliferation are poorly understood. Here we demonstrate in mice and humans that yes-associated protein 1 (YAP; also known as YAP1)--a protein known for its powerful growth-inducing and ...[more]