Unknown,Transcriptomics,Genomics,Proteomics

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Expression data from YAP-S127A Villin-rtTA crypts


ABSTRACT: We overexpressed YAP in the intestinal epithelium by adding doxycycline to the drinking water of experimental mice. Mice were given dox for 2 days, and referred to as Tg (transgenic). Mice were given dox for 2 days, sacrificed, and crypts were isolated for RNA extraction and analyzed by Affymetrix microarrays.

ORGANISM(S): Mus musculus

SUBMITTER: Fernando Camargo 

PROVIDER: E-GEOD-41506 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


A remarkable feature of regenerative processes is their ability to halt proliferation once an organ's structure has been restored. The Wnt signalling pathway is the major driving force for homeostatic self-renewal and regeneration in the mammalian intestine. However, the mechanisms that counterbalance Wnt-driven proliferation are poorly understood. Here we demonstrate in mice and humans that yes-associated protein 1 (YAP; also known as YAP1)--a protein known for its powerful growth-inducing and  ...[more]

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