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Yap role in intestine

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Fernando Camargo

PROVIDER: E-GEOD-41509 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Restriction of intestinal stem cell expansion and the regenerative response by YAP.

Barry Evan R ER Morikawa Teppei T Butler Brian L BL Shrestha Kriti K de la Rosa Rosemarie R Yan Kelley S KS Fuchs Charles S CS Magness Scott T ST Smits Ron R Ogino Shuji S Kuo Calvin J CJ Camargo Fernando D FD

Nature 20121125 7430

A remarkable feature of regenerative processes is their ability to halt proliferation once an organ's structure has been restored. The Wnt signalling pathway is the major driving force for homeostatic self-renewal and regeneration in the mammalian intestine. However, the mechanisms that counterbalance Wnt-driven proliferation are poorly understood. Here we demonstrate in mice and humans that yes-associated protein 1 (YAP; also known as YAP1)--a protein known for its powerful growth-inducing and ...[more]

PMID: 23178811

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