Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Daniela Schmitter
PROVIDER: E-GEOD-4246 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Schmitter Daniela D Filkowski Jody J Sewer Alain A Pillai Ramesh S RS Oakeley Edward J EJ Zavolan Mihaela M Svoboda Petr P Filipowicz Witold W
Nucleic acids research 20060913 17
RNA interference and the microRNA (miRNA) pathway can induce sequence-specific mRNA degradation and/or translational repression. The human genome encodes hundreds of miRNAs that can post-transcriptionally repress thousands of genes. Using reporter constructs, we observed that degradation of mRNAs bearing sites imperfectly complementary to the endogenous let-7 miRNA is considerably stronger in human HEK293 than HeLa cells. The degradation did not result from the Ago2-mediated endonucleolytic clea ...[more]