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Analysis of transcripts regulated by Dicer and Argonaute proteins in human HEK-293 cells

ABSTRACT: HEK-293-derived cell lines depleted of Dicer or one of four Argonaute proteins were generated. Microarray analysis of these knock down cell lines and various control cell lines was performed to address how large the proportion of genes is that are regulated by RNA silencing in an individual cell type. Comparison of different arrays revealed commonly (up) regulated genes. The highest overlap was observed in Ago2 and Dicer knockdown cells. Keywords: different timepoints of induction of stable knock down cell lines compared to various control cell lines

ORGANISM(S): Homo sapiens

PROVIDER: GSE4246 | GEO | 2006/09/01

SECONDARY ACCESSION(S): PRJNA94909

REPOSITORIES: GEO

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Transcription profiling of human HEK-293 cells to identify Dicer and Argonaute regulated gene expression

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