Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of effect of left ventricular assist device (LVAD) support on myocardium from human congestive heart failure patients


ABSTRACT: Molecular analysis of the effect left ventricular assist device (LVAD) support has on congestive heart failure patients.

ORGANISM(S): Homo sapiens

SUBMITTER: Yingjie Chen 

PROVIDER: E-GEOD-430 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Alterations of gene expression in failing myocardium following left ventricular assist device support.

Chen YingJie Y   Park Soon S   Li Yunfang Y   Missov Emil E   Hou Mingxiao M   Han Xinqiang X   Hall Jennifer L JL   Miller Leslie W LW   Bache Robert J RJ  

Physiological genomics 20030815 3


Chronic unloading of the failing heart with a left ventricular assist device (LVAD) can decrease cardiac mass and myocyte size and has the potential to improve contractile function. To study the effect of chronic ventricular unloading on myocardial gene expression, a microarray (U133A, Affymetrix) profiling gene expression was compared before and after LVAD support in seven patients with idiopathic dilated cardiomyopathy and end-stage heart failure. On average, 1,374 +/- 155 genes were reported  ...[more]

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