Unknown,Transcriptomics,Genomics,Proteomics

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Gene expression analysis of V5 tagged Sox17 expressing ES cells


ABSTRACT: Analysis of the expression of KH2 embryonic stem cells inducibly expressing V5 tagged Sox17 protein. Results provide information on the endodermal gene expression program activated after Sox17 expression in ES cells. Total RNA extracted from 48 hours doxycycline induced compaired to non-induced Sox17-V5 expressing ES cells

ORGANISM(S): Mus musculus

SUBMITTER: Irene Aksoy 

PROVIDER: E-GEOD-43233 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


How regulatory information is encoded in the genome is poorly understood and poses a challenge when studying biological processes. We demonstrate here that genomic redistribution of Oct4 by alternative partnering with Sox2 and Sox17 is a fundamental regulatory event of endodermal specification. We show that Sox17 partners with Oct4 and binds to a unique 'compressed' Sox/Oct motif that earmarks endodermal genes. This is in contrast to the pluripotent state where Oct4 selectively partners with Sox  ...[more]

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