Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Irene Aksoy
PROVIDER: E-GEOD-43233 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
The EMBO journal 20130308 7
How regulatory information is encoded in the genome is poorly understood and poses a challenge when studying biological processes. We demonstrate here that genomic redistribution of Oct4 by alternative partnering with Sox2 and Sox17 is a fundamental regulatory event of endodermal specification. We show that Sox17 partners with Oct4 and binds to a unique 'compressed' Sox/Oct motif that earmarks endodermal genes. This is in contrast to the pluripotent state where Oct4 selectively partners with Sox ...[more]